Fast to reverse diabetes

MANAGING DIABETES: Better to check fasting and post prandial blood glucose with

advanced digital glucometers may help diabetics to keep their diabetes under control.

A study on mice demonstrated reversal
A type of fasting diet may reprogramme pancreas cells, promote the growth of new insulinproducing
pancreatic cells and reduce symptoms of Type 1 and Type 2 diabetes, a study has
shown.

In the study, led by researchers from the University of Southern California, mice were placed
on fasting mimicking diet (FMD) for four days each week.
They showed remarkable reversal of diabetes.

The mice regained healthy insulin production, reduced insulin resistance.
They also demonstrated more stable levels of blood glucose — even in the later stages of the
disease, the researchers said in the paper published in the journal Cell.
The genes normally active in the developing pancreas of embryonic/foetal mice are

reactivated in diabetic adult mice when cycling FMD with normal diets.

This increases production of the protein neurogenin-3 (Ngn3) and, as a result, promotes the
creation of new, healthy insulin-producing beta cells.

Researchers also examined pancreatic cell cultures from human donors and found that, in
cells from Type 1 diabetes patients, nutrients mimicking fasting also increased expression of
the Ngn3 protein and insulin production.

“These findings warrant a larger FDA trial on the use of the Fasting Mimicking Diet to treat

diabetes patients,” said Valter Longo from the University of Southern California.
“People with diabetes could one day be treated with an FDA-approved Fasting Mimicking
Diet for a few days each month, eat a normal diet for the rest of the month, and see positive
results in their ability to control their blood sugar by producing normal levels of insulin and
improving insulin function,” Longo added.

Source: The Hindu