Foetus suffering from major congenital heart defects (MCHDs) may triple the risk of adverse pregnancy outcomes such as preeclampsia and preterm birth, finds a study.
MCHDs occur
in approximately 1 in 100 live births, and can negatively impact both the
health of the mother and the long-term outcomes for the child.
Researchers
from the Statens Serum Institut in Copenhagen showed that about 23 per cent of
pregnancies affected by foetal MCHD also result in adverse obstetric outcomes
including preeclampsia, preterm birth, fetal growth restriction, and placental
abruption.
The findings
were based on data from 534,170 pregnancies, including 745 cases complicated by
foetal MCHDs in Denmark. Pregnancies resulting in live births after 24
gestational weeks and without chromosomal aberrations were included in the
study.
The study,
published in JAMA Pediatrics, also assessed 11 MCHD subtypes, including
univentricular heart, transposition of the great arteries (TGA), and
atrioventricular septal defect.
Data on the
obstetric risk profile for specific MCHD subtypes are limited and thus slow
down the development of preventive interventions.
Pregnancies
complicated by MCHDs suffered an adverse obstetric outcome rate of 22.8 per
cent.
While foetal
growth restriction occurred in 6.7 per cent of MCHD pregnancies, a higher
prevalence of preeclampsia was found in 6.2 per cent of MCHD pregnancies.
They also
found a 15.7 per cent increased risk of preterm births in MCHD pregnancies.
While Placental abruption was rare it showed a significant trend toward higher
incidence 0.9 per cent.
All MCHD
subtypes, except TGA, were associated with significantly higher odds of the
composite adverse outcome. The highest risk was observed in pregnancies with
truncus arteriosus, pulmonary atresia with intact ventricular septum, and
Ebstein anomaly.
The team
also confirmed the findings with a meta-analysis of 5,993 cases of MCHDs.
Notably, pregnancies with fetal TGA did not exhibit elevated risks of
preeclampsia, preterm birth, or fetal growth restriction, the findings showed.
No comments:
Post a Comment