Australian researchers have made a major breakthrough in understanding OCD by identifying 250 genes linked to the disorder. The study analyzed DNA from over 50,000 people with OCD, revealing genetic connections to brain regions already associated with the condition. These findings could lead to faster diagnosis and more effective treatments, including repurposing existing medications. The research also highlights genetic overlaps with anxiety, depression, and eating disorders, underscoring OCD’s complexity.
May 15, 2025
Australian researchers identify genes behind obsessive-compulsive disorder
"We’ve been working on this for many years, but
these findings have dramatically increased our knowledge of the genetic basis
of OCD." – Eske Derks"
Australian researchers have identified genes linked
to obsessive-compulsive disorder (OCD), offering new hope for improved
diagnosis and treatment of the debilitating mental health condition.
Key Points
1 Study
analyzed DNA from 50,000 OCD patients
2 Genes
active in hippocampus and cerebral cortex
3 Genetic
overlap with anxiety and depression
4 Findings
could lead to repurposed treatments
OCD is a
mental condition and features a pattern of unwanted thoughts and fears known as
obsessions.
Researchers at QIMR Berghofer, formerly the
Queensland Institute of Medical Research, found 30 regions of the human genome
and around 250 genes associated with the disorder, Xinhua news agency reported.
The team identified the genes by analysing DNA from
more than 50,000 people with OCD and 2 million without the condition.
"We've been working on this for many years, but
these findings have dramatically increased our knowledge of the genetic basis
of OCD," said Eske Derks, lead researcher and head of the Translational
Neurogenomics Laboratory at QIMR Berghofer.
The genes identified are most active in the
hippocampus, striatum, and cerebral cortex, areas of the brain already linked
to OCD in previous neurological studies, according to the research, published
in the journal Nature Genetics.
The findings also showed significant genetic overlap
with other mental conditions such as anxiety, depression, anorexia, and other
eating disorders. The study further highlights OCD's complexity.
OCD affects approximately 1 per cent to 3 per cent
of the global population, ranging from compulsive cleaning and checking to
fears about causing harm, inappropriate thoughts, or obsessive doubts about
relationships and responsibilities.
"It not only impacts the individual but also
the family, because everyone is trying to accommodate the OCD," said
clinical psychologist Emily O'Leary.
She added that people with OCD are often trapped in
constant fear of doing something wrong or harming those they love.
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment