Osaka researchers use fat-derived stem cells to successfully treat spinal fractures in animal models, offering a promising non-invasive treatment for osteoporosis.
Japanese
Breakthrough: Stem Cells from Fat Regenerate Spinal Bone
Stem cells extracted
from adipose tissue cause minimal body stress during collection
Bone regeneration and
strength significantly improved in treated rat models
Genes involved in
bone formation were activated by the new treatment
The method combines
stem cell spheroids with beta-tricalcium phosphate material
A team of researchers
from Japan has successfully treated spinal fractures in animal models using
stem cells from fatty tissue.
"This technique
is expected to become a new treatment that helps extend the healthy life of
patients - Dr. Shinji Takahashi"
The team from the
Osaka Metropolitan University used stem cells extracted from adipose -- the
body’s fatty tissue -- to treat spine fractures in rats similar to those caused
by osteoporosis in humans.
These cells offer the
advantages of being easy to collect, even from elderly individuals, and causing
little stress to the body, suggesting a non-invasive way of treating bone
diseases.
Bone regeneration and
strength were significantly improved in rats transplanted with the adipose
tissue (ADSCs).
The genes involved in
bone formation and regeneration were also activated. The study was published in
Bone and Joint Research.
“This study has
revealed the potential of bone differentiation spheroids using ADSCs for the
development of new treatments for spinal fractures,” said Yuta Sawada, a
student at the varsity's Graduate School of Medicine.
“Since the cells are
obtained from fat, there is little burden on the body, ensuring patient safety.
This simple and effective method can treat even difficult fractures and may
accelerate healing,” added Dr. Shinji Takahashi.
Osteoporosis is a
disease that causes bones to become brittle and prone to fractures. Among
osteoporosis-related fractures, compression fractures of the spine -- known as
osteoporotic vertebral fractures -- are the most common type of fracture and
pose a serious problem, leading to a need for long-term care and a significant
decline in quality of life.
The team used stem
cells, which are multipotent, meaning that they can be differentiated into many
different cell types.
They developed ADSCs
into bone-differentiated spheroids -- three-dimensional spherical clusters --
and combined it with beta-tricalcium phosphate, a material widely used for bone
reconstruction, to successfully treat rats with spinal fractures.
“This technique is expected to become a new treatment that helps extend the healthy life of patients,” Takahashi said.
Japanese Stem Cell
Treatment Regenerates Spinal Bone
Japanese researchers have made a
significant breakthrough in bone regeneration using stem cells from fatty
tissue. The team from Osaka Metropolitan University successfully treated spinal
fractures in rats similar to those caused by human osteoporosis. Their
innovative approach uses adipose-derived stem cells that are easy to collect
and cause minimal stress to patients. This promising technique could lead to
new non-invasive treatments for difficult bone fractures.
https://www.newkerala.com/news/o/japaneseresearchers-successfullyregenerate-boneusing-stem-cells-466
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