March 31, 2023

Vitamin B12 deficiency: Are you at risk? Know the warning signs

Vitamin B12 is one of the vitamins which our body requires to perform several functions like making red blood cells and DNA.It also has a major role in the development of brain and nerve cells and hence are extremely essential for the generation of neurotransmitters. Apart from having a key role in the central nervous system, vitamin B12 supports bone health, prevents osteoporosis and fracture risk.

 Vitamin B12 also reduces the risk of macular degeneration, an eye disease that affects the central vision.This vitamin also helps improve mood and signs of depression.With so many functions, it is important to maintain the level of vitamin B12 in the body. Hence it is important to know the signs when the body lacks this vitamin so that you can replenish it.Here are few warning signs of vitamin B12 deficiency in the body.

Having balance problems while walking

Your walking pattern can reveal whether you are deficient of the vitamin that plays a pivotal role in the central nervous system.Difficulty in walking, having staggering problems, unable to balance during walking are the signs you need to have vitamin B12.

Anemia

Lack of vitamin B12 causes anemia. Also known as cobalamin deficiency, this condition develops when the body does not make sufficient red blood cells due to lack of vitamin B12, the vitamin which helps in the formation of the RBCs.Vitamin B12 anemia is characterized by shortness of breath, loss of appetite, vision issues, indigestion and headaches.

Swollen tongue

Lack of vitamin B12 leads to a condition called glossitis, a medical term that causes an inflammatory and painful tongue.Also known as beefy tongue, it is seen along with other symptoms like sores and lesions in the mouth, discoloration of the tongue and unexplainable burning sensations.

Cognitive difficulties

An essential element which has a major role in the brain functioning is ought to impact the cognitive abilities of an individual when it is not present sufficiently in the body.In this, the person experiences memory loss, has difficulty in thinking and reasoning.

Numbness in hands and legs

Numbness in limbs is always one of the key signs of vitamin B12 deficiency.Many people also experience tingling sensation. Unexplainable symptoms in the hands, legs or feet which affect the daily work of an individual can be linked to vitamin B12 deficiency.If this sign persists for a longer duration visit a doctor.

Other signs to watch out for

Apart from the warning signs, there are several other signs of vitamin B12 deficiency which one should be careful of.Due to lack of vitamin B12 one may experience fast heart rate, pale skin, fatigue, extreme weakness, mouth ulcers, increased irritability, low mood and decrease in appetite.

Where can you get vitamin B12 from?

You can get vitamin B12 from poultry, eggs, dairy and fish. It is mostly found in animal based foods.Older people, people who have gastrointestinal disorders, who are vegan, and have blood sugar problems are more at risk of being deficient in vitamin B12.

https://timesofindia.indiatimes.com/life-style/health-fitness/health-news/vitamin-b12-deficiency-are-you-at-risk-know-the-warning-signs/photostory/99057014.cms?picid=99057040

8 pharma firms producing spurious drugs lose licence

The Central Drugs Standard Control Organisation (CDSCO) and state drug controllers have cancelled the licences of 18 pharmaceutical companies for producing spurious drugs, official

sources said today. Besides, show-cause notices have been issued to 26 firms on the basis of joint inspections conducted by teams of the Drug Controller General of India (DCGI) and state regulators and drug controllers.

Action triggered by three int’l tragedies

Sonepat-based Maiden Pharma allegedly linked to the death of over 70 kids in Gambia

Noida-based Marion allegedly linked to the death of children in Uzbekistan

A Tamil Nadu-based firm allegedly linked to spurious eye drops that led to blindness and severe side-effects in the US

The officials did not share details of the erring firms, but said they had been hauled up over the production of substandard drugs. In all, 76 companies were inspected. The inspections, sources said, were part of a special drive conducted to check “red-flagged firms”. As many as 203 firms were identified for “special action”, of which 76 across 20 states and union territories were raided over the past fortnight, they said.

“The licences of 18 pharmaceutical companies have been cancelled for manufacturing spurious and adulterated drugs and for violating GMP (good manufacturing practice). Show-cause notices have been issued to 26 firms and the product manufacturing permission of three other firms has been cancelled,” a DCGI official said.

Among the 203 firms to be covered under the special drive, nearly 70 are in Himachal Pradesh, 45 in Uttarakhand and 23 in Madhya Pradesh. The inspections stem from three recent cases where exported Indian drugs have been found wanting. In October 2022, the WHO issued a global alert involving cold and cough medications made by Sonepat-based Maiden Pharma, which were allegedly linked to the death of over 70 children in Gambia.

Later, Noida-based Marion company was allegedly linked to the death of children in Uzbekistan. More recently, a Tamil Nadu-based firm was allegedly linked to spurious artificial eye drops that led to blindness and severe side-effects as reported by the US FDA in the US.

https://www.tribuneindia.com/news/nation/18-pharma-firms-producing-spurious-drugs-lose-licence-492079

WHO calls for intensified whole-of-government approach to end tuberculosis

The WHO South-East Asia Region bears the world’s highest tuberculosis burden

On World TB Day, WHO Friday called for an intensified whole-of-government and whole-of-society approach to end the disease globally.

It also highlighted the urgent need for strengthening high-level leadership and investments and accelerating the uptake of innovations and new recommendations of the world health body.

Globally, the COVID-19 pandemic has not just stalled but reversed years of progress towards ending tuberculosis, said WHO Regional Director for South-East Asia Dr Poonam Khetrapal Singh.

In 2021, the estimated burden of new and relapse tuberculosis cases globally was 10.6 million, a half-a-million increase from 2020. Mortality from TB and TB-HIV infection stood at 1.6 million, an increase of around 200,000 from pre-COVID-19 levels, she said.

In 2021, the region accounted for more than 45 per cent of global tuberculosis incidence and more than half of global TB deaths.

Throughout the COVID-19 pandemic, the region prioritised maintaining essential health services, including for TB. In 2020, it notified 2.6 million new and relapse TB cases, a 24 per cent reduction from 2019.

In 2021, the WHO South-East Asia region achieved a partial recovery, reporting 3 million new and relapsed cases, still 12 per cent fewer than in 2019, she said.

“The COVID-19 crisis has exacerbated key social and economic determinants of TB such as poverty and undernutrition, pushing tens of millions more people in the region into extreme poverty,” Khetrapal Singh said.

“Even before the pandemic, an estimated 30–80 per cent of tuberculosis patients in the (WHO’s south-east Asia) region faced catastrophic costs due to the disease and around 1 million new TB cases annually, more than one in five attributable to undernutrition,” she said.

It is estimated that across the region, the overall impact of the crisis could lead to over 7 million additional tuberculosis cases and 1.5 million additional deaths between 2022 and 2026, Khetrapal Singh said.

“Despite the ongoing challenges, the region continues to intensify action to achieve the end-TB milestones in line with its flagship priority and Regional Strategic Plan towards ending TB 2021–25, as well as the global End TB Strategy, the UN Political Declaration on the Fight Against TB, and Sustainable Development Goal 3.3.” The momentum must continue to build ahead of the second UN High Level Meeting on TB, scheduled for September 2023, she said.

For that, the Region has several priorities and the first among them is strengthening high-level leadership, engagement and advocacy to increase investments to end tuberculosis, Khetrapal Singh said.

The second is accelerating the uptake of new WHO recommendations and innovations. To date, more than 5,000 molecular test platforms have been deployed across the region to rapidly detect TB and drug resistance. Such platforms must continue to be scaled to ensure prompt diagnosis and treatment and to reduce spread.

In all countries, a new WHO-approved treatment regimen that has shown better cure rates in just six to nine months should be rapidly adopted and rolled out, Khetrapal Singh said.

The third is to aggressively address the social and economic determinants of TB, which are a major ongoing challenge. For this, mechanisms should be established and strengthened to support TB patients and their families to avoid catastrophic costs, supplement nutrition and promote treatment adherence.

https://www.tribuneindia.com/news/health/who-calls-for-intensified-whole-of-government-approach-to-end-tuberculosis-490918

Women with mental illness more than twice at risk of developing cervical cancer: Study

The observational study included over four million women born between 1940 and 1995

Women with mental illness, neuropsychiatric disability, or substance abuse run more than twice the risk of developing cervical cancer, as they are less likely to go for gynaecological smear tests, according to a study published in The Lancet Public Health.

The researchers at Karolinska Institutet, Sweden, stressed the importance of proactively approaching these women as a preventative measure against cervical cancer.

The observational study included over four million women born between 1940 and 1995.

In the women, the researchers compared women diagnosed by a specialist with mental illness, neuropsychiatric disability, or substance abuse with women without such diagnoses.

They then calculated the risk of cervical cancer and precancerous cervical lesions, including their participation in screening programs for cervical cancer.

“Our results suggest that women with these diagnoses participate more seldom in screening programs at the same time as they have a higher incidence of lesions in the cervix,” said one of the study’s first authors Kejia Hu, Institute of Environmental Medicine at Karolinska Institutet.

“We thus found that they have twice the risk of developing cervical cancer,” said Hu.

The greatest risk was observed for women with substance abuse, the researchers said.

Women with mental illness should be made more aware of the need to undergo regular gynaecological screening, they said.

“It would lower their risk of cancer,” says one of the paper’s authors Karin Sundström, senior researcher at the Department of Laboratory Medicine, Karolinska Institutet.

“Similarly, if healthcare professionals are more aware of the cancer risk in these patients, they can step up preventative measures and consider how these could be delivered to potentially under-served patients,” said Sundström.

One limitation of the study was that the researchers did not have full data about other risk factors for cervical cancer such as smoking, hormonal contraceptives, and sexually transmitted diseases, it said.

In May 2020, the World Health Organisation (WHO) approved a global strategy for eliminating cervical cancer as a women’s health problem.

Part of the strategy is a requirement that 70 percent of women are screened for the disease at least once before age 35 and twice before age 45.

According to the researchers, inequality of care is one of the major hurdles to this objective.

“Our study identified a high-risk group that needs extra attention if we’re to succeed in eliminating cervical cancer,” said Hu.

https://www.tribuneindia.com/news/health/women-with-mental-illness-more-than-twice-at-risk-of-developing-cervical-cancer-study-490921

Major anti-breast cancer drug off patent: Government in Parliament; room for cheaper generics

While the branded Palbociclib drug version cost over Rs 80,000 a month, the generic formulations now available have cut the drug cost by over 90 pc to around Rs 3800 a month

The government on Tuesday informed Parliament that a major anti-breast cancer drug, Palbociclib, had gone off patent, creating opportunities for production of generic versions..

The generic versions are currently either being produced or are in the process of being manufactured by around 15 pharmaceutical companies in India, health ministry sources said.

This was made possible after Pfizer’s Indian patent on Palbociclib expired on January 10 this year.

The Minister of State for Health in her answer on breast cancer drug availability, informed the Rajya Sabha today that as per the ICMR-National Cancer Registry Programme data, the estimated number of incidenceof breast cancer in the country for the year 2022 is 216108.

“As per Central Drugs Standard Control Organisation (CDSCO, palbociclib has gone offpatent on January 10, 2023.As informed by Department of Pharmaceuticals, National Pharmaceutical Pricing Authority vide dated February 27, 2019, has put a cap on Trade Margin of 42 selected nonscheduled anti-cancer medicines on pilot basis under ‘Trade Margin Rationalization’ approach. Anti-breast cancer drug Ribociclib was also included in this,” Pawar said.

Importantly nearly half the breast cancer patients detected annually out of around 14 lakh overall cancer patients, half (nearly 1.2 lakh) require Palbociclib, which is prescribed in combination with hormonal treatments.

Palbociclib is normally prescribed for 18 months with the generic drug version costing around Rs 3800 a month instead of Rs 80,000 previously.

Sun Pharmaceuticals was the first to launch a generic version of Pfizer’s palbociclib in India on January 11.

https://www.tribuneindia.com/news/health/major-anti-breast-cancer-drug-off-patent-government-in-parliament-room-for-cheaper-generics-492048

March 27, 2023

Dementia symptoms: Craving sweet foods could be an early warning sign you should not ignore

Uncommon signs of dementia

Dementia refers to a group of symptoms affecting your memory, thinking and social abilities. The impact can be severe enough to interfere with your daily life.

One of the most common types of dementia – Alzheimer's disease – is associated with memory loss in the early stages. However, frontotemporal dementia has other signs that may be dismissed or not taken seriously.

Parts of the brain affected by frontotemporal dementia are responsible for your personality, behaviors, and speech, according to the charity Dementia UK.

What is frontotemporal dementia?

Frontotemporal disorders (FTD), or frontotemporal dementia, result from damage to neurons in the frontal and temporal lobes of the brain. It most commonly affects people aged 40 to 60.There are two types of frontotemporal dementia – frontotemporal dementia behavioral variant (bvFTD) and primary progressive aphasia (PPA).

Link between food and dementia

According to the US National Institutes of Health, behavioral-variant frontotemporal dementia (bvFTD) is characterized by insidious changes in personality and interpersonal conduct.One such sign is changes in your behavior regarding food or drink, such as craving sweet foods. Further, you could be exhibiting poor table manners, overeating, or drinking too much alcohol.

Other signs of bvFTD

Apart from changes in eating habits, other signs of this variant include reduced motivation, lack of interest in things you used to enjoy and inappropriate behavior, e.g. making suggestive comments, staring, being over-familiar with people.Other signs include reduced empathy, difficulty focusing on tasks, obsessive or repetitive behavior and difficulty with planning, organizing and decision-making. You may not be aware or have insight that you are undergoing these changes.

Signs of primary progressive aphasia type

The primary progressive aphasia type affects your language rather than behavior.Symptoms include difficulty remembering, finding or understanding words; gradual loss of vocabulary and forgetting what common objects are and what they do, such as the role of kettle, toaster, keys.You may experience difficulty in forming sentences and using grammar correctly. Another sign includes difficulty finding words or conducting conversations. You may stop speaking mid-sentence, searching for the right word.

Treatment

There is no cure for dementia, however, treatment is there to help manage some of the symptoms. Antidepressants, prescribed by doctors, may help control symptoms like loss of inhibitions, overeating, or compulsive behaviors. Similarly, physiotherapy could help with movement issues and speech therapy could improve your communication skills.

https://timesofindia.indiatimes.com/life-style/health-fitness/health-news/dementia-symptoms-craving-sweet-foods-could-be-an-early-warning-sign-you-should-not-ignore/photostory/98993860.cms

Dry eyes, Myopia and more: 5 reasons you're getting these eye problems

The prevalence of non-communicable eye diseases is rising worldwide, especially in India. According to the findings of several worldwide research, Indians have a greater chance of developing diabetes and glaucoma-related vision issues, including total blindness. It is essential that eye disorders are identified early and the appropriate preventative measures are implemented on time in order to stop the numbers from rising.Dr. Sangeeta Shukla. Consultant Ophthalmology, Entod Pharmaceuticals says, “Many eye diseases are minor and don't persist for very long. However, some severe eye conditions can harm the eyes significantly, even resulting in permanent vision loss. Fortunately, most eye issues, even the most severe ones, may be avoided.”

Here is a list of some common preventable non-communicable diseases:

Dry Eyes

Dry eyes can significantly irritate the eyes and impede vision, typically in both eyes. The absence of tears, which are necessary to keep the eyes moist, healthy, and infection-free, is the root cause of dry eyes. You might not have any tears because your tears are evaporating faster or producing less of them. Decreased tear production is often due to things that cannot be avoided. These include:

ageing

underlying medical issues

use of certain medications

medical procedures

Precautions

Dr. Shukla advises, “Usually, increased tear evaporation can be avoided. Exposure to wind, smoke, or dry air are a few causes that are frequently cited for increased tear evaporation. On windy, dry days, you can prevent dry eyes by wearing sunglasses. You can also wear goggles if you work outdoors in windy, dry or smoky situations. Not blinking sufficiently can also cause dry eyes. When you pay close attention to something for an extended amount of time—such as reading, driving, or using a computer—this can occur. Take quick breaks from your work to rest your eyes in order to avoid this. Eye drops can also help in preventing dry eye.”

Glaucoma

Glaucoma happens to be a set of eye conditions that harm the optic nerve, which is necessary for clear vision. Exceptionally high pressure frequently results in this condition in the eye or eyes. Glaucoma can eventually cause irreversible blindness. Glaucoma typically runs in families but can also be brought on by diabetes, eye trauma and inactivity.

Precautions

According to Dr. Shukla, “There are steps you may take to stop your glaucoma from getting worse but not all cases of glaucoma can be prevented. Early glaucoma therapy has the highest success rate. The greatest way to prevent glaucoma, according to experts, is to get regular eye exams and screenings, especially if you have diabetes.

Regular exercise lowers ocular pressure which helps to prevent glaucoma. When using power tools or participating in sports that could harm your eyes, protective eyewear is also essential.”

Age-Related Macular Degeneration

Age-related macular degeneration is a prevalent disorder of the eyes, particularly in persons over 50. It harms the rear of the eye, making it difficult to view objects directly in front of you. Age-related changes in the eye are what lead to the disorder. As the condition progresses, vision loss also occurs in one or both eyes, causing a blurry area at the centre of vision that grows with time. However, some people are more susceptible than others to age-related macular degeneration. These include individuals who smoke, Caucasians and people with a history of the disease in their families.

Precautions

Researchers have discovered relationships between various lifestyle choices and age-related macular degeneration. According to experts, you can lower your risk of developing age-related macular degeneration by:

avoiding second-hand smoke,

regular exercise,

maintaining normal blood pressure and cholesterol levels

consuming a nutritious diet

Myopia

People who have myopia (also known as nearsightedness) have trouble seeing objects at a distance but can see objects clearly that are near. If you've myopia, you probably inherited it from one or both of your parents.

“Although myopia's specific cause is still unknown, eye specialists think a combination of inherited and environmental factors is to blame. It's possible to inherit the ability to be myopic and if your lifestyle creates the ideal circumstances, you'll eventually get it.” adds Dr. Shukla.

Precautions

Although myopia doesn't have any cure, there are everyday steps you can take to reduce the chances of developing myopia. Here are some tips:

Take screen breaks

Limit your time on digital devices

Don’t work or read in dim light

Spend time outdoors

Wear sunglasses while outside

Stop smoking

Wear protective eye gear for hobbies/sports

Schedule regular eye exams

Takeaway

The best way to prevent non-communicable eye diseases is to adhere to the steps mentioned above and most importantly, schedule regular exams.

https://timesofindia.indiatimes.com/life-style/health-fitness/health-news/dry-eyes-myopia-and-more-5-reasons-youre-getting-these-eye-problems/articleshow/98758429.cms

STDs: Warning signs you need to pay attention

‘The Martian’ Author Is Selling His Four-Level Suburban Chicago Home for $4.75 million

Sexually transmitte diseases like Chlamydia, Gonorrhea, Herpes, HIV, etc. begin with subtle signs which are the warning indicators for the individual to understand that the body is under threat and medical help is required.These diseases transmit from one individual to another through anal, oral and vaginal sex. Initially the symptoms appear to be mild, but when left untreated these spread faster and pose a bigger risk to the overall health.Here are few warning signs of STDs every individual should know:

Unusual discharge from private parts

If you notice unexplained fluid discharge from the vagina, penis or anus you should immediately seek a doctor's help.

Before visiting a doctor take note of the color of the discharge, whether it smells foul, the nature of the discharge and how frequently it happens.

Difficulty while urinating

Painful urination is an indication of an infection that has already happened in the private organs.Do not ignore it by bearing it despite it being uncomfortable.Many people try home remedies for this, but if the condition persists for longer duration visit a doctor.

Unusual growth in the skin of the genitals

If the skin folds of the genitals appear to be lumpy and uneven do not ignore it. Monitor it regularly and notice its growth, girth and if it is spreading to other body parts.

Itchy genitals

The pH levels of the bodily fluids helps the genitals keep themselves clean. It is also advisable to wash the private areas after sexual intercourse.However, if you notice itchiness in these areas which does not go away with regular hygiene practice then do not delay further and visit a doctor.Sores in the genitals

People often ignore the hygiene of the genitals and as a result of this unhealthy practice sores and blisters are seen in these areas.However, in case of STDs the blisters and sores are too stubborn and repetitive in nature.

Remotely connected signs to STDs

There are several signs of STDs which are remotely connected to the private areas.Signs like lower abdominal pain, painful bowel movements, fever, headache, sore throat, swollen lymph glands, rash, fatigue, diarrhea and weight loss are the symptoms of several STDs like HIV.

https://timesofindia.indiatimes.com/life-style/health-fitness/health-news/stds-warning-signs-you-need-to-pay-attention-to/photostory/98977321.cms?picid=98977333

WHO calls for intensified whole-of-government approach to end tuberculosis

The WHO South-East Asia Region bears the world’s highest tuberculosis burden

On World TB Day, WHO Friday called for an intensified whole-of-government and whole-of-society approach to end the disease globally.

It also highlighted the urgent need for strengthening high-level leadership and investments and accelerating the uptake of innovations and new recommendations of the world health body.

Globally, the COVID-19 pandemic has not just stalled but reversed years of progress towards ending tuberculosis, said WHO Regional Director for South-East Asia Dr Poonam Khetrapal Singh.

In 2021, the estimated burden of new and relapse tuberculosis cases globally was 10.6 million, a half-a-million increase from 2020. Mortality from TB and TB-HIV infection stood at 1.6 million, an increase of around 200,000 from pre-COVID-19 levels, she said.

The WHO South-East Asia Region bears the world’s highest tuberculosis burden.

In 2021, the region accounted for more than 45 per cent of global tuberculosis incidence and more than half of global TB deaths.

Throughout the COVID-19 pandemic, the region prioritised maintaining essential health services, including for TB. In 2020, it notified 2.6 million new and relapse TB cases, a 24 per cent reduction from 2019.

In 2021, the WHO South-East Asia region achieved a partial recovery, reporting 3 million new and relapsed cases, still 12 per cent fewer than in 2019, she said.

“The COVID-19 crisis has exacerbated key social and economic determinants of TB such as poverty and undernutrition, pushing tens of millions more people in the region into extreme poverty,” Khetrapal Singh said.

“Even before the pandemic, an estimated 30–80 per cent of tuberculosis patients in the (WHO’s south-east Asia) region faced catastrophic costs due to the disease and around 1 million new TB cases annually, more than one in five attributable to undernutrition,” she said.

It is estimated that across the region, the overall impact of the crisis could lead to over 7 million additional tuberculosis cases and 1.5 million additional deaths between 2022 and 2026, Khetrapal Singh said.

“Despite the ongoing challenges, the region continues to intensify action to achieve the end-TB milestones in line with its flagship priority and Regional Strategic Plan towards ending TB 2021–25, as well as the global End TB Strategy, the UN Political Declaration on the Fight Against TB, and Sustainable Development Goal 3.3.” The momentum must continue to build ahead of the second UN High Level Meeting on TB, scheduled for September 2023, she said.

For that, the Region has several priorities and the first among them is strengthening high-level leadership, engagement and advocacy to increase investments to end tuberculosis, Khetrapal Singh said.

The second is accelerating the uptake of new WHO recommendations and innovations. To date, more than 5,000 molecular test platforms have been deployed across the region to rapidly detect TB and drug resistance. Such platforms must continue to be scaled to ensure prompt diagnosis and treatment and to reduce spread.

In all countries, a new WHO-approved treatment regimen that has shown better cure rates in just six to nine months should be rapidly adopted and rolled out, Khetrapal Singh said.

The third is to aggressively address the social and economic determinants of TB, which are a major ongoing challenge. For this, mechanisms should be established and strengthened to support TB patients and their families to avoid catastrophic costs, supplement nutrition and promote treatment adherence.

Stigma and discrimination must continue to be tackled, including through community engagement and empowerment initiatives that promote high-quality information and include affected communities in all aspects of policy and programme design, planning and monitoring.

“The health sector alone cannot end tuberculosis. Rather, ending TB requires dedicated action from multiple sectors, which as highlighted at the 2021 Regional High-level Meeting to End TB, should be coordinated by national high-level mechanisms,” Khetrapal Singh added.

https://www.tribuneindia.com/news/health/who-calls-for-intensified-whole-of-government-approach-to-end-tuberculosis-490918

Women with mental illness more than twice at risk of developing cervical cancer: Study

The observational study included over four million women born between 1940 and 1995 disability, or substance abuse run more than twice the risk of developing cervical cancer, as they are less likely to go for gynaecological smear tests, according to a study published in The Lancet Public Health.

The researchers at Karolinska Institutet, Sweden, stressed the importance of proactively approaching these women as a preventative measure against cervical cancer.

The observational study included over four million women born between 1940 and 1995.

In the women, the researchers compared women diagnosed by a specialist with mental illness, neuropsychiatric disability, or substance abuse with women without such diagnoses.

They then calculated the risk of cervical cancer and precancerous cervical lesions, including their participation in screening programs for cervical cancer.

“Our results suggest that women with these diagnoses participate more seldom in screening programs at the same time as they have a higher incidence of lesions in the cervix,” said one of the study’s first authors Kejia Hu, Institute of Environmental Medicine at Karolinska Institutet.

“We thus found that they have twice the risk of developing cervical cancer,” said Hu.

The greatest risk was observed for women with substance abuse, the researchers said.

Women with mental illness should be made more aware of the need to undergo regular gynaecological screening, they said.

“It would lower their risk of cancer,” says one of the paper’s authors Karin Sundström, senior researcher at the Department of Laboratory Medicine, Karolinska Institutet.

“Similarly, if healthcare professionals are more aware of the cancer risk in these patients, they can step up preventative measures and consider how these could be delivered to potentially under-served patients,” said Sundström.

One limitation of the study was that the researchers did not have full data about other risk factors for cervical cancer such as smoking, hormonal contraceptives, and sexually transmitted diseases, it said.

In May 2020, the World Health Organisation (WHO) approved a global strategy for eliminating cervical cancer as a women’s health problem.

Part of the strategy is a requirement that 70 percent of women are screened for the disease at least once before age 35 and twice before age 45.

According to the researchers, inequality of care is one of the major hurdles to this objective.

“Our study identified a high-risk group that needs extra attention if we’re to succeed in eliminating cervical cancer,” said Hu.

https://www.tribuneindia.com/news/health/women-with-mental-illness-more-than-twice-at-risk-of-developing-cervical-cancer-study-490921

Obesity risk may be passed on from moms to daughters: Study

It is a common, serious and costly disease affecting nearly half of the adults and 20 percent of

children in the United States

According to a recent study published in the Journal of Clinical Endocrinology & Metabolism

of the Endocrine Society, mothers with obesity may share the disease's risk with their daughters

but not with their sons.

Obesity is a common, serious and costly disease affecting nearly half of the adults and 20

percent of children in the United States. It costs an estimated $173 billion in medical care costs.

People with obesity are at higher risk of developing diabetes, high blood pressure, heart issues,

and many other conditions.

"These findings highlight that girls born to mothers who have obesity or have high amounts of

body fat may be at higher risk of gaining excess body fat themselves," said Rebecca J. Moon,

B.M., Ph.D., M.R.C.P.C.H., of the MRC Lifecourse Epidemiology Centre, University of

Southampton in Southampton, U.K. "Further studies are needed to understand why this is

happening, but our findings suggest that approaches to addressing body weight and

composition should start very early in life, particularly in girls born to mothers with obesity

and overweight." The researchers measured body fat and muscle in 240 children (9 years old

or younger) and their parents in early childhood. They used this data to determine whether the

body mass index (BMI)--a screening tool for overweight and obesity--and the amount of body

fat and muscle in the child was related to that of their parents.

They found the girls had similar BMI and fat mass to their mothers, suggesting that girls born

to mothers who have obesity or have high fat mass are at high risk of also developing obesity

or overweight. The researchers did not find the same association between boys and their

mothers or either girls or boys and their fathers.

https://www.tribuneindia.com/news/health/obesity-risk-may-be-passed-on-from-moms-todaughters-

study-491213

Epilepsy may raise risk of early death, reveals new study on the eve of Purple Day

Purple Day is celebrated annually on March 26 to raise epilepsy awareness.

People with epilepsy have an increased risk of early death, according to a new study ahead of Purple Day.

The study, published in the journal Neurology, showed that people with epilepsy had more than twice the risk of death compared to the overall population.

The increased risk was even higher in younger people in the study of 20,095 epilepsy patients.

The increased risk also varies depending on where they live, the number of medications they take and what other diseases they may have, the researchers said.

"Our research found an increased risk even among those who do not have other health problems and are taking only one medication to control their seizures," said study author Seo-Young Lee, MD, PhD, of Kangwon National University in Chuncheon, South Korea.

Epilepsy accounts for a significant proportion of the world affecting 50 million people worldwide.

Each year, an estimated 5 million people are diagnosed with epilepsy.

According to Ravindra Srivastava, Director, Neurosciences, Primus Super Speciality Hospital, in India, more than 10 million patients are suffering with epilepsy, 20 per cent out of 50 million worldwide.

"If you witness someone having a seizure, it is essential to stay calm and keep the person safe, protect the person's head, turn the person on their side to help prevent choking, time the seizure, do not restrain the person and stay with the person until they are fully alert and oriented," Srivastava said.

https://www.tribuneindia.com/news/health/epilepsy-may-raise-risk-of-early-death-reveals-new-study-on-the-eve-of-purple-day-491241

March 24, 2023

Colon cancer symptoms: As colorectal cancer cases increase in India, do not miss these early signs

Cancer, as we all know, is the second leading cause of death globally. March is observed as the Colorectal Cancer Awareness Month. Receiving an early diagnosis when it comes to any cancer is crucial, but sometimes the symptoms can mimic signs of other stomach or issues with intestines. So how do we tell it apart? We spoke to Dr. Ramanjit Singh, Director and Head of Colorectal Surgery, GI Surgery, Medanta Gurugram to know more about the third most common cancer in India.

Are colorectal cancers on the rise?

Colorectal cancer is one of the common cancers in the body. Overall, it's the third most common cancer of the body and each one of us has around 4-5 per cent lifetime risk of developing colorectal cancer. Moreover, initially it was thought that maybe it's a white man's disease. But now if you see, it's actually the incidence is increasing like an epidemic. So just like diabetes, now we have an epidemic of colorectal cancers even in India. So that is the reason we all are interested in this topic and that is the reason for celebrating this month to make people aware about how we can prevent it, how we can treat it so that we can diagnose it early.

“I'm a surgeon. So for a surgeon, we usually see around 250-300 surgeries, patients who need surgery. So there are many patients who just have polyps, who have early cancer, they are even treated by the gastroenterologist by endoscopy only. And there are other cases which are diagnosed late. So those cases are treated by the medical oncologist with chemotherapy only. So if you ask about surgery, it's around 250-300 cases of surgical patients.”

Signs of colon cancer people tend to miss

Yes, so there are actually features like a recent change in bowel habit. If somebody was having constipation, now suddenly develops diarrhea or somebody was having diarrhea since long 3-4 motions a day. Now he or she is constipated. So that is the most common symptom, recent change in bowel habit. Others include bleeding rectum, any patient with unexplained weight loss. So if you're doing exercise and losing weight, that's a different thing. So you're not doing anything, you're not doing any dietary restriction and still you're having weight loss. So then it's an indicator that we are missing something or any patient with unexplained anemia. So you get your routine test, your hemoglobin is 6 grams. So that means we are losing blood somewhere. So these are the most common features which are usually seen, recent change in bowel habit, unexplained weight loss, unexplained anemia or bleeding for rectum.

Anybody with these symptoms which we call as a worrisome symptoms or anybody who is at a high risk group should get tested. There are some patients who are more prone to colorectal cancer. So if you are in one of those categories, probably then you need screening in terms of a curled blood test, CEA or in terms of colonoscopy.

What puts you at risk?

Patients who have a family history of colorectal cancer, somebody like a father, mother, brother had colorectal cancer or there are patients who had some kind of a colonic polyp which has been excised, maybe early childhood or something are at risk. Other patients who have some inflammatory conditions of the intestine like ulcerative colitis, Crohn's disease or there are some genetic syndromes like familial adenomatous polyposis. There is another HNPCC. So this is a kind of syndrome where colorectal cancer runs in the family. So the chances of a person developing colorectal cancer in these genetic syndromes is actually close to 100%. So if you are any of these high risk groups, it makes you a definite candidate for getting screened at an early stage.

Colorectal cancer is actually one of the cancers in the body which we call a lifestyle disease. So there are a lot of dietary factors, a lot of lifestyle factors which are associated with colorectal cancer. So if you see the lifestyle, obesity has been shown to increase the risk of colorectal cancer. So this assertion has actually been proven, especially in men, smoking, alcoholism, they also predispose one to colorectal cancer.

How can you protect yourself?

There is another study which has shown that a sedentary lifestyle increases the risk. There are studies which have shown that if you exercise four hours a week, vigorous activity, it has shown to have a protective effect. There are some other factors like dietary factors. So it is important to increase fiber intake, vitamin C, E, as they are all protective against colorectal cancer. And there are some dietary factors like red meat, processed meats, refined grains, high fat dairy products, starch, and sugar. All of these factors increase the risk of colorectal cancer.

Colorectal cancer is actually a disease of the elderly population. So anybody more than 60 is definitely more prone. But unfortunately, in recent years, we are now finding a young population, even less than 40 with colorectal cancer. And majority of these, they have a genetic, some kind of mutation. Otherwise, it was actually a disease of elderly population only.

Colorectal cancers are 100% curable

Among all other cancer, colorectal cancers, if diagnosed early, is 100% curable. So if you find a polyp, you excise it, the patient is cured. He does not even need a follow up. If it is diagnosed at an early stage, there is a good 90% survival rate, which is not seen in any cancer in the body. Even if it's diagnosed late, suppose it's a stage 3 cancer, we still have treatment options in the form of surgery. There are a lot of chemotherapy drugs to which colorectal cancer responds. And even if you have cancer, which is stage 4, and has spread to other parts of the body like liver, lungs, still we can treat them with chemotherapy and long term survival is still possible. So it's not the case that if somebody gets colorectal cancer, he's gone or it's an analytic approach. That is not the case. So still, if you get early treatment, long term survival is possible in colorectal cancers.

https://timesofindia.indiatimes.com/life-style/health-fitness/health-news/colon-cancer-symptoms-as-colorectal-cancer-cases-increase-in-india-do-not-miss-these-early-signs/articleshow/98939351.cms

Do pills for PCOS really help?

PCOS is a chronic endocrinological condition that affects various facets of your health, including your reproductive, metabolic and psychological. But with awareness, early identification of symptoms and proper guidance it can be managed.

Lifestyle modification, dietary changes, and exercise are the first line of treatment and are the most effective solution for the long term but some women may need medical management as well.

Do all women with PCOS need medications?

Short answer, no. Depending on the woman's symptoms, medical history and any co-morbidities, a doctor can evaluate if medications are needed. Some commonly prescribed medications are oral contraceptive pills or birth control pills, metformin (insulin-sensitising drug) and sometimes nutraceuticals like myoinositol supplement. Some women with PCOS who aren't able to conceive naturally after making lifestyle modifications can be prescribed ovulation-inducing drugs to help stimulate ovulation and increase the chances of pregnancy.

Medications are not a bad thing

Taking medications is often seen as a failure to manage PCOS - this is not true. One of the reasons why women hesitate to take medication is because they want to either manage it on their own or "naturally". But in PCOS, sometimes treating the underlying hormonal imbalance may require more than just making lifestyle changes. Taking medications can actually give you the time to make lifestyle corrections, lose weight and follow a healthy routine.

Most medications prescribed for PCOS are only a temporary correction to help regulate hormones that are imbalanced. These medicines help achieve the required therapeutic window which may not be achieved naturally for the patient. Having said that, taking medications is not a replacement for making lifestyle modifications. Lifestyle changes with medications make the therapy the most effective.

What are the common medications for PCOS?

There is no single pill or treatment method for PCOS. Medications are usually prescribed to correct hormonal imbalances which can in turn mitigate symptoms like irregular periods, weight gain, hirsutism, acne and scalp hair loss, among others.

Oral contraceptives or birth control pills Apart from protecting from unwanted pregnancies, oral contraceptive pills (OCPs) are effective in regularising period cycles and reducing male hormone levels. OCPs don't make you infertile, nor do they affect your chances of getting pregnant. Once you stop taking it, your ovaries are expected to function smoothly if the underlying cause of PCOS is managed by then.

Metformin

Metformin is a drug which is usually prescribed for diabetic patients to reduce blood sugar levels by improving the insulin sensitivity of the peripheral tissues (muscles). Since nearly 70 per cent of women with PCOS suffer from insulin resistance, taking metformin can help reduce insulin resistance, and thereby the production of androgens as well (male hormones). This can in turn help with weight loss, re-establish regular periods and improve your chances of conceiving.

Anti-androgen drugs

Increased levels of androgens or male hormones can cause symptoms such as excess facial hair, acne and scalp hair loss. Anti-androgen drugs are prescribed to help reduce male hormone levels and improve the symptoms. However, anti-androgen drugs are usually prescribed after lifestyle changes and 6 months of oral conceptive pills course hasn't shown improvements.

Ovulation inducing drugs

Women with PCOS who have had trouble getting pregnant can be prescribed ovulation-inducing drugs. Letrozole is a widely used drug for the treatment of sub-fertility in women with PCOS and has been shown to be more effective than other medications such as clomiphene citrate. Other medications such as metformin and gonadotropins can also help stimulate ovulation.

Medications form an important part of treating PCOS, and there is nothing wrong with taking medications to manage your symptoms. Although not all women may need it, medications for PCOS are very effective in treating hormonal imbalances and help you get on top of your PCOS and manage it with greater confidence.

https://www.tribuneindia.com/news/health/do-pills-for-pcos-really-help-490632

Hidden 'super spreaders' spur dengue fever transmission: Study

The number of "hidden" infections tied to a place, or cases of infected people who show no symptoms, could be the key indicator for dengue risk, suggests a new study.

So far, for mosquito-borne diseases such as dengue fever, the abundance of the insects in places where people gather has served as the main barometer for infection risk.

The new study, published in the journal PNAS Nexus, found that 8 per cent of human activity spaces accounted for more than half of infections during a dengue outbreak. And these "super spreader" spaces were associated with a predominance of asymptomatic cases, or 74 per cent of all infections.

"That's the complicated nature of this virus. We have underestimated the role of asymptomatic cases in spreading dengue," Gonzalo Vazquez-Prokopec, Associate Professor of environmental sciences at Emory University said.

"Symptomatic cases represent only the tip of the iceberg," he added Generally, about 50 to 70 per cent of dengue cases are asymptomatic, making detection by public health officials impractical, but the study reveals that asymptomatic cases are tied to a third of transmission.

"The lesson is that we need to focus on prevention of dengue outbreaks," Vazquez-Prokopec said. "The interventions for dengue for decades have been reactive. Simply reacting by closing a net around reported cases of the disease, however, will fail to contain an outbreak because that's missing the super spreaders." For the study, the researchers wanted to determine the role of asymptomatic cases. People without symptoms may continue to go about their daily routines,

unknowingly infecting any mosquitoes that bite them, which can then later spread the virus to more people.

The study involved 4,600 people in two different neighbourhoods in the Amazonian city of Iquitos in Peru, a dengue hotspot.

They were surveyed three times a week about their mobility. This data was used to map "activity spaces," such as residences, churches and schools.

Blood analyses confirmed a total of 257 symptomatic cases of dengue during the six-year study period. That led to investigations of other participants whose activity spaces overlapped with the symptomatic cases. More than 2,000 of these location-based contacts were confirmed by blood tests to have dengue infections and more than half of them reported not having any noticeable symptoms.

The results pinpointed the role of asymptomatic "super spreaders" in a dengue outbreak. A small number of the activity spaces, or 8 per cent, were linked to more than half of the infections and most of the cases associated with those places were asymptomatic.

"We found that the mosquito numbers in a location alone is not a predictor of the risk of infection," Vazquez-Prokopec said.

Instead, risk prediction for a location requires a cascade of circumstances -- a high number of asymptomatic cases frequenting the location combined with high levels of mosquitos and high numbers of people who are not immune to the particular serotype of dengue virus that is circulating.

"For diseases that are directly spread from one person to another, like Covid-19, what matters is who you were near," he said. "But in the case of dengue, what matters most is where you went." IANS

https://www.tribuneindia.com/news/health/hidden-super-spreaders-spur-dengue-fever-transmission-study-490637

Hormonal birth control pills linked with small breast cancer risk: Study

The resaerchers at the University of Oxford, UK, and colleagues found that a 15-year absolute excess incidence is at most 265 cases per 100,000 users

Use of all hormonal contraceptives is associated with a small increase in the risk of breast cancer, according to a new study.

The research, published in the journal PLOS Medicine, found a relative increase of 20 to 30 per cent in breast cancer risk associated with both combined and progestogen-only contraceptives, whatever the mode of delivery.

The resaerchers at the University of Oxford, UK, and colleagues found that a 15-year absolute excess incidence is at most 265 cases per 100,000 users.

Use of combined oral contraceptives, containing both estrogen and progestogen hormones, has previously been associated with a small increase in breast cancer risk but there is limited data about the effect of progestogen-only contraceptives, the resaerchers said.

However, the use of progestogen-only contraceptives has increased substantially in recent years, with almost as many prescriptions in England for oral progestogen-only contraceptives as for combined oral contraceptives in 2020, they said.

The researchers analysed data from a UK primary care database, the Clinical Practice Research Datalink (CPRD), on 9,498 women under the age of 50 with invasive breast cancer diagnosed in 1996–2017, as well as data on 18,171 closely matched controls.

On average, 44 per cent of women with breast cancer and 39 per cent of matched controls had a hormonal contraceptive prescription, with about half the prescriptions being for progestogen-only preparations.

With five years use of either oral combined or progestogen-only contraceptives, the associated 15-year absolute excess incidence of breast cancer was estimated at 8 cases per 100,000 hormonal contraceptive users at age 16–20 years and 265 cases per 100,000 users at age 35–39 years.

The odds of breast cancer were similarly and significantly raised, regardless of whether the contraceptive used was a combined (estrogen and progestogen) oral preparation, a progestogen-only oral preparation, an injected progestogen, or a progestogen releasing intra-uterine device.

These results were combined with those from previous studies from high income countries, which included women from a wider age range.

“These findings suggest that current or recent use of all types of progestogen-only contraceptives is associated with a slight increase in breast cancer risk, similar to that associated with use of combined oral contraceptives,” said Kirstin Pirie of University of Oxford.

“Given that the underlying risk of breast cancer increases with advancing age, the absolute excess risk associated with use of either type of oral contraceptive will be smaller in women who use it at younger rather than at older ages,” Pirie said.

However, the resaerchers said these excess risks must be viewed in the context of the well-established benefits of contraceptive use in women’s reproductive years.

https://www.tribuneindia.com/news/health/hormonal-birth-control-pills-linked-with-small-breast-cancer-risk-study-490650


Covid: Highest weekly case positivity in Himachal, 8 states driving surge

Mock drill in hospitals soon, no rise in deaths, hospitalisations: Union health secretary

The government on Thursday said eight states were contributing to the recent Covid surge, with the maximum case positivity detected in Himachal Pradesh in the week ending March 23 adding that a mock drill across hospitals would be held soon to monitor health system preparedness.

Noting that the pandemic was not over, Union health secretary Rajesh Bhushan said India was currently contributing only 1 pc of the new daily global cases as against US (19 pc) and Russia (12.6 pc).

As of today, global daily new Covid cases average 94,000 with the US contributing 18,000, Russia 11,856, China 7,778, South Korea 7,519, France 6,798, and India 966.

“Average daily cases in India have risen from 108 in the week ending February 19 to 966 in the week ending March 23 with weekly positivity up from 0.09 % in February second week to 1 pc in the week ending March 23,” Bhushan said adding that all circulating variants in India were Omicron sub lineages including two lineages—XBB 1.5 and XBB 1. 1.6 which have been designated variants of interest to study whether they escape immunity.

Bhushan said eight states contributing to India’sburden are Maharashtra, Gujarat, Karnataka, Tamil Nadu, Delhi, Kerala, Himachal Pradesh and Rajasthan.

Weekly case positivity is 7 per cent in Himachal, 4.49 per cent in Maharashtra and 4.17 per cent in Gujarat, the states with highest positivity in India.

Bhushan added that India has so far seen 196 XBB 1.5 variant cases this year, and these rose from 46 in January to 103 in February and 47 in March.

XBB 1.1.6 cases rose correspondingly in these three months from 2 to 138 and 24 taking the total this year to 344.

“There is no evidence of any increase in hospitalisation and mortality. XBB 1.16 variants have been detected from Maharashtra (105 cases), Telangana 93, Karnataka 57, Gujarat 54, and Delhi 19. Over 90 pc Indians aged 12 years and above have completed the primary two dose Covid vaccination schedule with only 27 pc having received booster doses,” Bhushan said.

The government said all currently circulating variants in India are sub variants of Omicron. ”Since the emergence of Omicron in 2021, close to 1000 lineages have been assigned,” Bhushan said, adding that India has stepped up genomesurveillance to detect any new variants.

https://www.tribuneindia.com/news/nation/covid-highest-weekly-case-positivity-in-himachal-8-states-driving-surge-490691

Suffering from endometriosis or adenomyosis? Here's the difference

Adenomyosis and endometriosis are two common conditions that affect women's reproductive health. People often get confused between adenomyosis and endometriosis as the symptoms of the two conditions can be very similar. Both conditions involve the growth of endometrial tissue outside of its usual location in the uterus, and both can cause heavy menstrual bleeding, severe menstrual cramps, chronic pelvic pain, and pain during sex. In addition, both conditions can be difficult to diagnose because the symptoms often mimic other gynaecological conditions.Dr. Priyanka Suhag, Consultant - Obstetrics & Gynaecology, CK Birla Hospital (R), Delhi says, “Adenomyosis and endometriosis can sometimes occur together. Studies have shown that up to 50% of women with endometriosis may also have adenomyosis. When these two conditions occur together, the treatment can be challenging. However, there are a few differences between the two that can help people to distinguish the two conditions.” 

Location of tissue growth

The main difference between adenomyosis and endometriosis is the location of abnormal growth of tissue. Adenomyosis occurs when endometrial tissue grows inside the muscular wall of the uterus, while endometriosis occurs when endometrial tissue grows outside of the uterus, such as on the ovaries, fallopian tubes, or other organs in the pelvic area.

Age and childbearing history

Adenomyosis and endometriosis also tend to affect women at different stages in their reproductive lives. Adenomyosis is more common in women over the age of 30 who have had children or multiple pregnancies, while endometriosis is more common in women in their 20s and 30s who have not had children.

Symptoms

According to Dr. Suhag, the symptoms of adenomyosis and endometriosis can be similar, there are some differences in the way they manifest. Adenomyosis causes more heavy and prolonged menstrual bleeding, while endometriosis may cause more pain during sex, painful bowel movements or urination during periods, and in some cases infertility.

Diagnosis

Diagnosing adenomyosis and endometriosis can involve different procedures. Adenomyosis is detected through imaging tests such as ultrasound or MRI, while a biopsy of the uterine tissue may be needed to confirm the diagnosis. On the other hand, endometriosis may be diagnosed through a laparoscopy, which is a minimally invasive surgical procedure that allows doctors to visualize the tissue from outside the uterus.

Treatment

The treatment options for adenomyosis and endometriosis can also differ. Hormonal birth control may be effective for managing symptoms of both conditions, however, adenomyosis may require more aggressive treatments such as uterine artery embolization or even hysterectomy in severe cases. Surgery to remove endometrial tissue or scar tissue may be recommended for women with endometriosis and assisted reproductive technologies may be needed for those experiencing infertility.“While adenomyosis and endometriosis share some similarities in terms of symptoms and causes, there are important differences between the two conditions that require proper diagnosis and treatment. If someone is experiencing symptoms of either condition, it's important to consult a doctor to get an accurate diagnosis and discuss the most appropriate treatment options for the condition with their gynaecologists,” says Dr. Suhag.

https://timesofindia.indiatimes.com/life-style/health-fitness/health-news/suffering-from-endometriosis-or-adenomyosis-heres-the-difference/photostory/98910929.cms


Eating handful of nuts & seeds daily can lower heart risk by 25%

Want to boost your heart health? Eating a handful of nuts and seeds can help you reduce the risk of heart disease by 25 per cent, according to a new study.

The study showed nuts lower cholesterol levels and are linked to a lower risk of cardio-vascular disease. By eating nuts, you reduce your risk of suffering or dying from a heart attack.

One of the reasons is the composition of fatty acids in nuts, the researchers said.

"Even though nuts cannot be used to treat high cholesterol, we believe that the effect is significant enough to be used as a preventive measure amongst the general population," Erik Arnesen, research fellow at the University of Oslo said.

Researchers from the University of Oslo in Norway and the Karolinska Institute in Sweden conducted a systematic review and meta-analysis of 60 previous studies.

"If you eat a handful of nuts every day, that is around 30 grams, you will have a 20 to 25 per cent lower risk of suffering from cardiovascular disease. Many people do not eat nuts or seeds at all," Arnesen said, in the paper published in the journal Food & Nutrition Research

Arnesen emphasised that even though scientists say "the more the better", eating just a few nuts is better than none at all.

Almonds, pistachios and walnuts appear to be the best for lowering cholesterol, but according to Arnesen there is so far no conclusive evidence for recommending specific kinds of nuts over and above others.

"Nuts have a beneficial effect on cholesterol levels in the blood, which is important to keep low in order to prevent the build-up of fat in the arteries. This atherosclerosis, as it is called, is one of the greatest risk factors for heart attacks," he explained.

However, the researchers were uncertain whether eating nuts reduces the risk of strokes and diabetes Type 2.

"We are not sure about this. Nuts do not appear to affect blood pressure, which is one of the risk factors behind strokes. We cannot be sure whether nuts are good for blood sugar levels either, which are linked to the risk of diabetes Type 2," Arnesen said.

https://www.tribuneindia.com/news/health/eating-handful-of-nuts-seeds-daily-can-lower-heart-risk-by-25-490335

March 22, 2023

Omega-3 deficiency: Brittle nails and dry skin could be a sign; higher risk of heart disease

While our bodies require a range of vitamins, minerals and other nutrients to stay healthy, it is not always possible to meet the required levels, especially if you are not paying attention to your diet. This can lead to deficiency and accompanied troubling symptoms.

One such problem is omega-3 deficiency. Omega-3 fatty acids are needed by the body for creating the regulating hormones for blood clotting as well as contraction and relaxation of artery walls which pump your blood. EPA and DHA found in omega-3 also help with your cognitive function, skin health and vision. Here are some signs which may indicate omega-3 deficiency in your body.

Omega-3 fatty acids help your skin to absorb healthy nutrients and get rid of harmful waste products. Lack of this healthy fat can lead to dry skin as well as skin rashes. You may also have a flaky and itchy scalp.

Dry, broken, and brittle nails can also be a symptom of omega-3 deficiency. Omega-3 fatty acids are vital to reduce inflammation in your nail bed.

Omega-3 fats are essential for nourishing your locks and supporting luscious, thick hair. Therefore, a deficiency can lead to hair loss due to undernourished skin cells and hair follicles.

Other common symptoms of this deficiency include poor concentration and general fatigue.

Long-chain omega-3 fatty acids are crucial for keeping your heart healthy. According to experts, a lack of omega-3 could raise the risk of heart disease and stroke.

Omega-3 fatty acids also help to lower triglycerides levels in your body, high levels of which can put you at a higher risk of heart disease and stroke.

The body can’t make omega-3 from scratch. Some foods you can eat to increase your consumption of omega-3 fatty acids include:

Vegetable oils, flax seeds, hemp seeds, chia seeds, spinach and walnuts. Seafood is also a great source including oily fish like salmon, sardines, herring and anchovies; and some shellfish like oysters, clams and mussels.

What to do if you are deficient?

Consult a doctor if you think you may be lacking omega-3 fatty acids. Increasing the amount of omega-3-rich ingredients in your diet may alleviate deficiency symptoms. Talk to your doctor if you plan to take omega-3 supplements.

https://timesofindia.indiatimes.com/life-style/health-fitness/health-news/omega-3-deficiency-brittle-nails-and-dry-skin-could-be-a-sign-higher-risk-of-heart-disease/photostory/98858313.cms

Researchers discover key feature of severe allergic reaction

Findings could point to new targets for therapies to prevent or treat anaphylactic shock

An abrupt drop in blood pressure and body temperature is a key feature of the severe allergic reaction known as anaphylaxis, causing people to faint and, if untreated, potentially die.

This response has long been attributed to blood vessel dilation and leakage. However, Duke Health researchers discovered in a mouse study that this response, particularly body temperature drop, requires an additional mechanism -- the nervous system.

The findings published in the journal Science Immunology, the study could point to new targets for therapies to prevent or treat anaphylactic shock, which occurs in up to 5% of people in the U.S. annually in response to food allergies or bites from insects or venomous animals.

"This finding for the first time identifies the nervous system as a key player in the anaphylactic response," said senior author Soman Abraham, Ph.D., professor in the departments of Pathology, Immunology, and Molecular Genetics and Microbiology at Duke University School of Medicine.

"The sensory nerves involved in thermal regulation - especially the nerves that sense high environmental temperatures - send the brain a false signal during anaphylaxis that the body is exposed to high temperatures even though it is not the case," Abraham said. "This causes a rapid drop in body temperature as well as blood pressure." Abraham and colleagues, including first author Chunjing "Evangeline" Bao, a Ph.D. candidate in Abraham's lab at Duke, tracked the sequence of events when allergens activate mast cells -- the immune cells that trigger the chemical reactions leading to swelling, difficulty breathing, itchiness, low blood pressure and hypothermia.

The researchers found that one of the chemicals mast cells unleash when they are activated is an enzyme that interacts with sensory neurons, notably those involved in the body's thermoregulatory neural network.

When stimulated as part of an allergic reaction, this neural network gets the signal to immediately shut down the body's heat generators in the brown fat tissue, causing hypothermia. The activation of this network also causes a sudden drop in blood pressure.

The researchers validated their findings by showing that depriving mice of the specific mast cell enzyme protected them against hypothermia, whereas directly activating the heat sensing neurons in mice induced anaphylactic reactions such as hypothermia and hypotension.

"By demonstrating that the nervous system is a key player - not just the immune cells - we now have potential targets for prevention or therapy," Bao said. "This finding could also be important for other conditions, including septic shock, and we are undertaking those studies.

https://www.tribuneindia.com/news/health/researchers-discover-key-feature-of-severe-allergic-reaction-489448

Mediterranean diet may cut heart disease, death risk in women by 25 per cent

Cardiovascular disease accounts for more than a third of all deaths in women around the world

Women follow a Mediterranean diet to improve your heart health and reduce your risks of cardiovascular disease and death by nearly 25 per cent, suggests a study.

The Mediterranean diet is rich in wholegrains, vegetables, fruit, legumes, nuts, and extra virgin olive oil; moderate in fish/shellfish; low to moderate in wine; and low in red/processed meats, dairy products, animal fat, and processed foods.

Cardiovascular disease accounts for more than a third of all deaths in women around the world. While a healthy diet, including Mediterranean diet, has been a key plank of prevention, most relevant clinical trials have included relatively few women or haven't reported the results by sex, the researchers said.

The new study, published in the journal Heart, is the first to focus on the association between a Mediterranean diet and incident CVD and death, specific to women.

"We found that a Mediterranean diet was beneficial in women, with a 24 per cent lower risk of CVD and a 23 per cent lower risk of total mortality," said researchers including from the University of Sydney.

The risk of coronary heart disease was 25 per cent lower, while that of stroke was also lower, although not statistically significant, in those who most closely followed this diet compared with those who did so the least.

The Mediterranean diet's antioxidant and gut microbiome effects on inflammation and cardiovascular risk factors are among the possible explanations for the observed associations, the researchers said.

In addition, the diet's various components, such as polyphenols, nitrates, omega-3 fatty acids, increased fibre intake and reduced glycaemic load, may all separately contribute to a better cardiovascular risk profile.

"However, mechanisms explaining the sex specific effect of the Mediterranean diet on (cardiovascular disease) and death remain unclear," they note, adding that the findings reinforce the need for more sex specific research in cardiology.

"Female specific cardiovascular risk factors, including premature menopause, pre-eclampsia and gestational diabetes, or female predominant risk factors, such as systemic lupus, can all independently increase (cardiovascular disease) risk," the researchers said.

For the data analysis, the researchers included 16 published studies involving more than 700,000 women aged 18 and above.

The researchers also acknowledged various limitations to their findings, including that all the studies analysed were observational and relied on self-reported food frequency questionnaires.

https://www.tribuneindia.com/news/health/mediterranean-diet-may-cut-heart-disease-death-risk-in-women-by-25-per-cent-489450

PGI to help make cutting edge AI-based healthcare tools

Post Graduate Institute of Medical Education and Research (PGIMER) here has been designated as a centre of excellence for artificial intelligence (AI) in healthcare by the Ministry of Health. The move comes as the Central Government ramps up its efforts to promote the creation and use of AI-based solutions in healthcare.

The PGIMER is a premier medical education and research institute that has made significant contributions to the field of medicine over the years. Its expertise will be leveraged to develop AI-based tools that can aid healthcare professionals in providing accurate diagnosis and expert assistance to patients.

Project aimed at creating robust healthcare system

A significant step towards achieving the Centre’s vision of creating a robust and accessible healthcare system for all citizens.

By breaking data silos and creating a longitudinal electronic health record of every citizen, the project will integrate cutting-edge technologies with the existing health IT applications.

It has the potential to revolutionise healthcare by making the latest AI-based technologies available to healthcare professionals.

Recently, the PGIMER developed a project, which was aimed at collecting a database of cancer-related radiology and pathology images from Indian patients and storing it digitally. The AI tools developed from this database will work with high precision on Indian patients, thereby assisting general radiologists or pathologists in providing accurate diagnoses at just the click of a button.

The project is a multi-institutional research effort involving leading healthcare institutions such as Tata Memorial Hospital (TMH), Mumbai; AIIMS, New Delhi; and Rajiv Gandhi Cancer Institute, New Delhi. The collaboration is aimed at pooling resources and expertise to create a robust AI-based solution that can improve the accuracy and efficiency of healthcare services in India.

The centre of excellence for AI in healthcare is a significant step towards achieving the Indian Government’s vision of creating a robust and accessible healthcare system for all citizens. The government’s Ayushman Bharat Digital Mission (ABDM) is aimed at enabling the interoperability of health data within the health ecosystem, thus creating a longitudinal Electronic Health Record (EHR) of every citizen.

By breaking data silos and creating a longitudinal EHR of every citizen, the project will integrate cutting-edge technologies such as AI and blockchain with the existing health IT applications to improve the performance of health services.

The project has the potential to revolutionise healthcare in India by making the latest AI-based technologies available to healthcare professionals. With the rapid advancements in AI-based technologies, this centre of excellence for AI in health care will play a critical role in harnessing the power of AI to improve the quality of health care services in India.

The NITI Aayog of the Centre has also published two approach documents on AI for India, emphasising the need for responsible and ethical use of AI in healthcare and other sectors. The documents provide guidelines for the development and deployment of AI-based solutions, ensuring that these are safe, trustworthy and respect privacy and human rights.

https://www.tribuneindia.com/news/chandigarh/pgi-to-help-make-cutting-edge-ai-based-healthcare-tools-489596

How bad is vaping and should it be banned?

Vaping regularly makes headlines, with some campaigning to make e-cigarettes more available to help smokers quit, while others are keen to see vaping products banned, citing dangers, especially for teens.

So just how dangerous is it? We have undertaken an evidence check of vaping research. This included more than 100 sources on tobacco harm reduction, vaping prevalence and health effects, and what other countries are doing in response. Here's what we found.

How does vaping compare to smoking?

Smoking is harmful. It's the leading preventable cause of death in Australia. It causes 13% of all deaths, including from lung, mouth, throat and bladder cancer, emphysema, heart attack and stroke, to name just a few. People who smoke regularly and don't quit lose about ten years of life compared with non-smokers.

Nicotine, a mild stimulant, is the active ingredient in both cigarettes and nicotine vaping products. It's addictive but isn't the cause of cancer or the other diseases related to smoking.

Ideally, people wouldn't be addicted to nicotine, but having a safe supply without the deadly chemicals, for instance by using nicotine patches or gum, is safer than smoking. Making these other sources available is known as “harm reduction”.

Vaping is not risk-free, but several detailed reviews of the evidence plus a consensus of experts have all estimated it's at least 95% safer to vape nicotine than to smoke tobacco. The risk of cancer from vaping, for example, has been estimated at less than 1%.

These reviews looked at the known dangerous chemicals in cigarettes, and found there were very few and in very small quantities in nicotine vapes. So the argument that we won't see major health effects for a few more decades is causing more alarm than is necessary.

Is ‘everyone' vaping these days?

Some are concerned about the use of vaping products by teens, but currently available statistics show very few teens vape regularly. Depending on the study, between 9.6% and 32% of 14-17-year-olds have tried vaping at some point in their lives.

But less than 2% of 14-17-year-olds say they have used vapes in the past year. This number doubled between 2016 and 2019, but is still much lower than the rates of teen smoking (3.2%) and teen alcohol use (32%).

It's the same pattern we see with drugs other than alcohol: a proportion of people try them but only a very small proportion of those go on to use regularly or for a long time. Nearly 60% of people who try vaping only use once or twice.

Smoking rates in Australia have declined from 24% in 1991 to 11% in 2019 because we have introduced a number of very successful measures such as restricting sales and where people can smoke, putting up prices, introducing plain packaging, and improving education and access to treatment programs.

But it's getting harder to encourage the remaining smokers to quit with the methods that have worked in the past. Those still smoking tend to be older, more socially disadvantaged, or have mental health problems.

Should we ban vapes?

So we have a bit of a dilemma. Vaping is much safer than smoking, so it would be helpful for adults to have access to it as an alternative to cigarettes. That means we need to make them more available and accessible.

But ideally we don't want teens who don't already smoke to start regular vaping. This has led some to call for a “crackdown” on vaping.

But we know from a long history of drug prohibition - like alcohol prohibition in the 1920s - that banning or restricting vaping could actually do more harm than good.

Banning drugs doesn't stop people using them - more than 43% of Australians have tried an illicit drug at least once. And it has very little impact on the availability of drugs.

But prohibition does have a number of unintended consequences, including driving drugs underground and creating a black market or increasing harms as people switch to other drugs, which are often more dangerous.

The black market makes drugs more dangerous because there is no way to control quality. And it makes it easier, not harder, for teens to access them, because there are no restrictions on who can sell or buy them.

Are our current laws working?

In 2021, Australia made it illegal to possess and use nicotine vaping products without a prescription. We are the only country in the world to take this path.

The problem is even after more than a year of this law, only 8.6% of people vaping nicotine have a prescription, meaning more than 90% buy them illegally.

Anecdotal reports even suggest an increase in popularity of vaping among teens since these laws were introduced. At best, they are not helping.

It may seem counterintuitive, but the way to reduce the black market is to make quality-controlled vapes and liquids more widely available, but restricted to adults. If people could access vaping products legally they wouldn't buy them on the black market and the black market would decline.

We also know from many studies on drug education in schools that when kids get accurate, non-sensationalised information about drugs they tend to make healthier decisions. Sensationalised information can have the opposite effect and increase interest in drugs. So better education in schools and for parents and teachers is also needed, so they know how to talk to kids about vaping and what to do if they know someone is vaping.

What have other countries done?

Other countries allow vapes to be legally sold without a prescription, but impose strict quality controls and do not allow the sale of products to people under a minimum age. This is similar to our regulation of cigarettes and alcohol.

The United Kingdom has minimum standards on manufacturing, as well as restrictions on purchase age and where people can vape.

Aotearoa New Zealand introduced a unique plan to reduce smoking rates by imposing a lifetime ban on buying cigarettes. Anyone born after January 1, 2009 will never be able to buy cigarettes, so the minimum age you can legally smoke keeps increasing. At the same time, NZ increased access to vaping products under strict regulations on manufacture, purchase and use.

As of late last year, all US states require sellers to have a retail licence, and sales to people under 21 are banned. There are also restrictions on where people can vape.

A recent study modelled the impact of increasing access to nicotine vaping products in Australia. It found it's likely there would be significant public health benefits by relaxing the current restrictive policies and increasing access to nicotine vaping products for adults.

The question is not whether we should discourage teens from using vaping products or whether we should allow wider accessibility to vaping products for adults as an alternative to smoking. The answer to both those questions is yes.

The key question is how do we do both effectively without one policy jeopardising the outcomes of the other?

If we took a pragmatic harm-reduction approach, as other countries have done, we could use our very successful model of regulation of tobacco products as a template to achieve both outcomes.

https://www.tribuneindia.com/news/health/how-bad-is-vaping-and-should-it-be-banned-490033

Long Covid infection linked with risk of 'face blindness': Study

Prolonged symptoms of COVID-19 may be associated with difficulty recognising faces, a little-known condition called face blindness, and navigational problems, according to a study.

Previous studies have shown that COVID-19 can cause a range of neurological problems, including the loss of smell and taste, and impairments in attention, memory, speech, and language, known as "brain fog".

The latest research, published in the journal Cortex, is the first to report prosopagnosia, or face blindness, following symptoms consistent with COVID-19.

The condition that can make people fail to recognise familiar faces, has been estimated to affect between 2 and 2.5 per cent of people in the world.

The researchers assessed the case of Annie, a 28-year-old customer service representative and part-time portrait artist in the US, who was diagnosed with COVID-19 in March 2020 and suffered a symptom relapse two months later.

"When I first met Annie, she told me that she was unable to recognise the faces of her family," said Marie-Luise Kieseler, a graduate student at Dartmouth College in the US, adding Annie now relies on voices to recognise people.

Annie also experienced navigational deficits after having COVID-19. She has had difficulty remembering where particular sections in her grocery store are and relies on Google maps and its pin function to remember where she parks her car.

“The combination of prosopagnosia and navigational deficits that Annie had is something that caught our attention because the two deficits often go hand in hand after somebody either has had brain damage or developmental deficits,” said study senior author Brad Duchaine, a professor at Dartmouth.

"That co-occurrence is probably due to the two abilities depending on neighbouring brain regions in the temporal lobe," Duchaine said in a statement.

Dr. Vinit Suri, Senior Consultant, Neurology, Indraprastha Apollo Hospitals, New Delhi noted that the exact mechanisms by which long Covid may cause face blindness are not yet fully understood, but there are several possible explanations.

"Firstly, long Covid can cause a range of neurological symptoms which may affect the brain regions responsible for face recognition, causing difficulty in processing visual information and recognising familiar faces," Suri told PTI.

"Secondly, Covid-19 can cause inflammation and damage to the blood vessels, which can lead to reduced blood flow to the brain. This can cause brain damage and cognitive impairments, including face blindness," he added.

The research team conducted a series of tests with Annie to evaluate her problems with face recognition and determine whether she also has difficulties with other perceptual or cognitive abilities.

In one test, Annie was sequentially presented with 60 images of celebrity faces and was asked to name them. Annie correctly identified 29 per cent of the 48 celebrities whom she was familiar with as compared to most people, who can correctly identify 84 per cent of familiar celebrities.

The second test was a doppelganger test. Annie was shown a celebrity's name and then presented with images of two faces: the face of a celebrity and that of someone similar, and was then asked to identify which face was the famous person.

She identified the celebrity in 69 per cent of the 58 trials, as compared to 87 per cent in the control group.

"Our results from the test with unfamiliar faces show that it wasn't just that Annie couldn't recall the name or biographical information of a famous person that she was familiar with, but she really has trouble learning new identities," said Kieseler.

The research team also obtained self-reported data from 54 individuals who had long COVID with symptoms for 12 weeks or more, and 32 persons who had reported that they had fully recovered from COVID-19.

Most respondents with long COVID reported that their cognitive and perceptual abilities had decreased since they had COVID.

"It was not just a small concentration of really impaired cases but a broad majority of people in the long COVID group reported noticeable difficulties doing things that they were able to do before contracting COVID-19 without any problems," Kieseler said.

"Our study highlights the sorts of perceptual problems with face recognition and navigation that can be caused by COVID-19 -- it is something that people should be aware of, especially physicians and other health care professionals,” Duchaine added.

Dr. Atul Prasad, Principal Director & HOD Neurology, BLK-Max Super Speciality Hospital, New Delhi said this is the first report of long COVID causing prosopagnosia.

"The more we study the virus, the more we realise how much damage it can cause during acute infection and now after infection has settled," Prasad told PTI.

people with long Covid will develop face blindness, and the severity and duration of symptoms can vary widely.

"Further research is needed to better understand the relationship between long Covid and face blindness and to develop effective treatments and interventions for those affected," he added.

https://www.tribuneindia.com/news/health/long-covid-infection-linked-with-risk-of-face-blindness-study-490047

Study finds how lymph nodes boost tumor cells after success of immunotherapy

According to new research, therapies may cause lymph nodes to produce tumour-fighting T cells.

Typically, lymph nodes close to the tumour are removed as part of cancer treatment in case they harbour metastatic cancer cells. Nevertheless, recent study from a clinical trial conducted by Gladstone Institutes and UC San Francisco researchers demonstrates that immunotherapy can activate tumour-fighting T cells in surrounding lymph nodes.

The study, published in Cell, suggests that leaving lymph nodes intact until after immunotherapy could boost efficacy against solid tumors, only a small fraction of which currently respond to these newer types of treatments.

Most immunotherapies are aimed only at reinvigorating T cells in the tumor, where they often become exhausted battling the tumor's cancer cells. But the new research shows that allowing the treatment to activate the immune response of the lymph nodes as well can play an important role in driving positive response to immunotherapy.

"This work really changes our thinking about the importance of keeping lymph nodes in the body during treatment," said Matt Spitzer, PhD, an investigator for the Parker Institute for Cancer Immunotherapy and Gladstone-UCSF Institute of Genomic Immunology and senior author of the study. Lymph nodes are often removed because they are typically the first place metastatic cancer cells appear, and without surgery, it can be difficult to determine whether the nodes contain metastases.

"Immunotherapy is designed to jump start the immune response, but when we take out nearby lymph nodes before treatment, we're essentially removing the key locations where T cells live and can be activated," Spitzer said, noting that the evidence supporting the removal of lymph nodes is from older studies that predate the use of today's immunotherapies. Aim for the Lymph Nodes, Not the Tumor Researchers have largely been working under the assumption that cancer immunotherapy works by stimulating the immune cells within the tumor, Spitzer said. But in a 2017 study in mice, Spitzer showed that immunotherapy drugs are actually activating the lymph nodes. "That study changed our understanding of how these therapies might be working," said Spitzer.

Rather than the immunotherapy pumping up the T cells in the tumor, he said, T cells in the lymph nodes are likely the source for T cells circulating in the blood. Such circulating cells can then go into the tumor and kill off the cancer cells. Having shown that intact lymph nodes can temper cancer's hold in mice, Spitzer's team wanted to know whether the same would prove true in human patients. They chose to design a trial for patients with head and neck cancers because of the high number of lymph nodes in those areas.

The trial enrolled 12 patients whose tumors hadn't yet metastasised past the lymph nodes. Typically, such patients would undergo surgery to remove the tumor, followed by other treatments if recommended.

Instead, patients received a single cycle of an immunotherapy drug called atezolizumab (anti-PD-L1) that is produced by Genentech, a sponsor of the trial. A week or two later, Spitzer's team measured how much the treatment activated the patients' immune systems.

The treatment also included surgically removing each patient's tumor and nearby lymph nodes after immunotherapy and analyzing how the immunotherapy affected them. The team found

that, after immunotherapy, the cancer-killing T cells in the lymph nodes began springing into action.

They also found higher numbers of related immune cells in the patients' blood. Spitzer attributes some of the trial's success to its design, which allowed the team to get a lot of information from a small number of patients by looking at the tissue before and after surgery and running detailed analyses.

"Being able to collect the tissue from surgery shortly after the patients had been given the drug was a really unique opportunity," he said. "We were able to see, at the cellular level, what the drug was doing to the immune response."

That kind of insight would be challenging to get from a more traditional trial in patients with later-stage disease, who would not typically benefit from undergoing surgery after immunotherapy. Metastases Inhibit Immune Response Another benefit of the study design was that it allowed researchers to compare how the treatment affected lymph nodes with and without metastases, or a second cancer growth.

"No one had looked at metastatic lymph nodes in this way before," said Spitzer.

"We could see that the metastases impaired the immune response relative to what we saw in the healthy lymph nodes." It could be that the T cells in these metastatic nodes were less activated by the therapy, Spitzer said. If so, that could explain, in part, the poor performance of some immunotherapy treatments. Still, the therapy prompted enough T-cell activity in the metastatic lymph nodes to consider leaving them in for a short period of time until treatment ends. "Removing lymph nodes with metastatic cancer cells is probably still important but taking them out before immunotherapy treatment may be throwing the baby out with the bathwater," said Spitzer. A subsequent goal of the current trial is to determine whether giving immunotherapy before surgery protects against the recurrence of tumors in the future. Researchers won't know the answer to that until they've had a chance to monitor the participants for several years. "My hope is that if we can activate a good immune response before the tumor is taken out, all those T cells will stay in the body and recognize cancer cells if they come back," Spitzer said.

https://www.tribuneindia.com/news/health/study-finds-how-lymph-nodes-boost-tumor-cells-after-success-of-immunotherapy-490051

March 21, 2023

H3N2 Influenza

H3N2 Influenza: Most effective techniques to diagnose it; know if you are at risk

H3N2 Influenza hospitalisations are on rise in India; children and elderly could be most at risk. Know the risk factors and the best ways to diagnose it.

H3N2 Influenza virus has been increasing the number of hospitalisation cases in Delhi and surrounding areas and while most cases out of the 1000 detected in the country have been mild, government advisory has warned people to take precautions like cleanliness, preventing crowding, and hand hygiene. Children below 6 years and adults above 65 years have been asked to take special precautions as they are among the vulnerable group.

All viral respiratory illnesses be it influenza A- H3N2, H1N1 variant, novel coronavirus 19, and omicron sub variant, are steadily increasing, because of host of environmental factors 

Respiratory diseases may be on rise this spring due to a host of factors from pollution, festive gatherings, lack of hand hygiene, and lowered immunity among others. It is important to distinguish H3N2 influenza symptoms from those of Covid as while the latter is said to last for 2-3 days and the patient recovers soon, H3N2 and H1N1 can stretch for a couple of weeks and may even has more chances of leading to pneumonia or a secondary bacterial infection, say experts.

"Currently approximately 30 per cent of patients visit with symptoms of upper or lower respiratory issues. Symptoms are more or less the same for any viral illness- sore throat, dry cough, headache, myalgia, diarrhoea, only difference is that in the present clinical scenario, Covid symptoms barely last for 2-3 days and the patient recovers soon without any hassles and any major treatment. Whereas with H3N2 and H1N1 has more predilection for productive and wet coughs which lasts longer for a few weeks and has more chances of getting pneumonia or a secondary bacterial infection. Irrespective of the virus if there is a major comorbid factor there are more chances of morbidity and mortality,"

Dr Samrat Shah, Senior Consultant, Internal Medicine, Sir HN Reliance Foundation Hospital told HT Digital.

Elaborating on the causes of rise in respiratory infections, Dr Shah said, "in the current scenario, all viral respiratory illnesses be it influenza A- H3N2, H1N1 variant, novel coronavirus 19, and omicron sub variant, these are steadily increasing, because of host of environmental factors. Some of the host factors are avoidance of face masks, casual attitude towards general health, lack of hand hygiene, and more social gatherings. Some of the environmental factors contributing to the increase in cases are poor air quality and excessive construction pollution. The only way to prevent this influenza virus complication is by vaccinating once a year with the quadrivalent flu vaccine."

Why there is surge of Influenza infections and hospitalisations in India

"India is currently seeing a surge in influenza viral infections due to H3N2. Influenza A viruses infect humans and many different animals. The emergence of a new and very different influenza A virus with the ability to infect people and have sustained human to human transmission, can cause an influenza pandemic and therefore is of most significance to public health," says Dr Sunita Kapoor, Director and Consultant Pathologist at City X-ray & Scan Clinic.

"Influenza type A viruses are classified into subtypes according to the combinations of different virus surface proteins, hemagglutinin (HA) and neuraminidase (NA). Current subtypes of influenza A viruses that routinely circulate in people include A(H1N1) and A(H3N2). In years in which H3N2 is the predominant strain, there are more hospitalisations. Human infections are primarily acquired through direct contact with infected animals or contaminated environments, these viruses have not acquired the ability of sustained transmission among humans," adds Dr Kapoor.

Who is at risk from H3N2 influenza virus

Dr Kapoor says small children and elderly are among those who are most at risk of this virus while pregnant women, those with weakened immune system, chronic illnesses and travellers might be at risk of this virus too.

Here are those who are at risk of H3N2 influenza virus:

- Young children under age 2

- Adults older than age 65

- Residents of nursing homes and other long-term care facilities

- People who are pregnant or plan to be pregnant during flu season

- People with weakened immune systems

- People who have chronic illnesses, such as asthma, heart disease, kidney disease, liver disease and diabetes

- Health care workers performing aerosol generating procedures.

- Travelers to countries and people living in countries with known outbreaks of avian influenza

Diagnosis of H3N2 virus

Dr Kapoor says influenza virus detection techniques have been classified into four categories:

- Traditional methods, e.g., viral culture serological methods, e.g., immunofluorescence assays, complement fixation, immunodiffusion test, virus neutralization method, hemagglutination method, rapid antigen testing.

- Advanced quick methods which include NAT (Nucleic acid tests) like RT PCR, multiplex PCR, nucleic acid sequence-based amplification (NASBA), and conventional PCR.

- Bio-sensing methods which include includes optical biosensors, giant magneto-resistance biosensors, aptamer-based biosensors, and electrochemical biosensors

Nucleic acid-based tests

"Nucleic acid tests (NAT) employ PCR and virus-specific RNA or DNA sequences/genetic material instead of viral antibodies or antigens. These are much more susceptible and specific as compared to serological assays and can diagnose viruses in many earlier clinical samples. An antibody-based test takes time because the human body cannot make antibodies instantly at a detectable level. Therefore, NAT can overcome this limitation of serological methods. Most of these methods take 2–4 hours to complete the detection," says Dr Kapoor.

RT-PCR

This technique is considered the most powerful tool for the detection of the influenza virus. Nested primers are utilised to detect and subtype influenza viruses. The results of this test present extremely high sensitivity and specificity, the greatest of all traditional detecting approaches.

https://www.hindustantimes.com/lifestyle/health/most-effective-techniques-to-diagnose-h3n2-influenza-know-if-you-are-at-risk-101679298594219.html