Washington, May 24: A study headed by Michigan Medicine indicates that stresses across the
lifespan, such as poverty, abuse, and divorce, are linked to deteriorating health and functional
outcomes in patients with multiple sclerosis.
Using survey data frommore than 700 people with MS, researchers discovered that stressful events
occurring both in childhood and adulthood contributed significantly to participants' level of
disability.
The results are published in Brain and Behavior.
"MS is the leading cause of non-traumatic disability among young adults, and additional research
is needed to identify these external drivers of disability that can be addressed or prevented,
including stress, to improve functional outcomes," said co-author Tiffany Braley, M.D., M.S.,
director of the Multiple Sclerosis/Neuroimmunology Division and Multidisciplinary MS Fatigue
and Sleep Clinic at University of Michigan Health.
"This knowledge is needed to inform MS research as well as clinical care. Referrals to resources,
such as mental health or substance use support could help reduce the impact of stress and enhance
wellbeing," Braley said.
More than 2.8 million people in the world haveMS, an autoimmune condition that affects the brain
and spinal cord, in which the protective layer of nerve cells is attacked by the body's immune
system. People with MS can experience unique, often painful, exacerbations of their symptoms
known as a relapses, exacerbations or "flares".
Initially in the study, both childhood and adult stressors were significantly associated with worse
burden caused by relapse after the onset of the COVID-19 pandemic. However, the association
between childhood stressors and disease burden lost significance when further accounting for
experiences in adulthood.
Studies focused on stress and MS that don't account for the full lifespan, researchers say, could
miss vital information or overestimate the relationship between childhood stressors and health
outcomes.
"Adverse Childhood Experiences, which we call ACEs, and other childhood stressors could impact
immune, inflammatory and behavioral processes throughout life, and reduce resilience to adult
stress," said first author Carri Polick, Ph.D., R.N., who completed this work while at the U-M
School of Nursing and is now a postdoctoral fellow in the National Clinician Scholars Program at
Duke University.
"It is important to use a lifespan approach in future work to better understand patterns and inform
symptom management. For example, we are expanding upon this work to investigate mechanistic
pathways through sleep, smoking and mental health, through which stressors may lead to worse
MS outcomes including increased disability, pain and fatigue."
No comments:
Post a Comment