A study shows new insights on how damaged cells interact with disease-infested micro environments following acute kidney injury (AKI).
AKI is a serious global health hazard, especially
community-acquired AKI (CA-AKI).
In nations like India, the International Society of
Nephrology's "0 by 25" slogan, with the goal to eliminate unnecessary
fatalities from AKI to zero by 2025 is unachievable, presumably because there
is a dearth of information and action to address this pressing public health
concern, especially in third world countries that struggle with the most basic
of needs, owing to factors like low GDP, income disparity, less access to
resources, etc.
A study using a cutting-edge tool called seqFISH, developed
by University of South California and Caltech, has found that over 1,000 genes
in damaged kidney tissue can be analysed. The researchers identified
micro-environments associated with injury and predicted cellular interactions
associated with the progression to chronic kidney disease (CKD). This could
help identify targets for preventing kidney failure and CKD.
Scientists have identified a pathological micro-environments
in the kidney's outermost layer, which they named"ME-5," which
contains a proximal tubule cell (PT) -- the cell that filters waste from blood,
located in the kidneys, vulnerable to injury.
In ME-5, injured PTs and fibroblasts exchange signals
promoting inflammation and fibrosis.
Another injury-associated micro-environments, dubbed
"ME-16", contains tertiary lymphoid structures -- a place in the body
where immune cells gather to fight diseases, contributing to chronic
inflammation, distributed throughout the injured organ, which is what makes
things worse in patients, because it does not stay in one place only, it
spreads to other organs in the vicinity, making things much more debilitated
for the patient.
We're ecstatic that advances in technology have made it
possible to comprehend kidney illness and injury on a deeper level. The value
of interdisciplinary and cross-institutional cooperation in advancing
biomedical research is demonstrated by this study, although further experiments
like this will help cement this as a reliable treatment, Dr. Long Cai, a
Professor of Biology and Biological Engineering at Caltech noted.
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